It doesn't incorporate all details about the achievable utilizes, Instructions, warnings, precautions, interactions, adverse consequences, or pitfalls that will apply to modafinil. This details is not specific clinical tips and does not replace information and facts you get within the Health care supplier. You will need to speak with the healthcare supplier for total details about the hazards and advantages of working with this drugs.
Allergic reactions which include rash, angioedema, anaphylaxis, and Stevens–Johnson syndrome might almost never be brought on by an immunological reaction to modafinil or its metabolites.
To be able to attain a prescription for modafinil, a affected person will need to have a valid professional medical cause of using the drug, such as narcolepsy or obstructive rest apnea. Moreover, the prescription must be prepared by a licensed doctor and filled in a licensed pharmacy. The use of modafinil for non-healthcare functions, such as While using the purpose to further improve cognitive functionality or to remain awake for extensive periods of time, is strictly prohibited and may end up in lawful outcomes.[184][185]
triclabendazole will increase the degree or result of modafinil by impacting hepatic enzyme CYP2C19 metabolism.
EMA ble opprettet i 1995 for å sikre most effective mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av legemidler.
Additionally, some researchers feel that modafinil may perhaps communicate with certain proteins or enzymes which have been linked to the breakdown and elimination (
Hold out from the arrive at of youngsters. This medicine is often abused. click here Keep your medicine in a secure put to protect it from theft. Tend not to share this drugs with any individual. Advertising or giving away this medicine is hazardous and from the legislation.
modafinil will minimize the extent or outcome of levoketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
Both equally kinds may cause abnormal daytime sleepiness. Research advise that modafinil may be a promising drug that could lower both of those daytime sleepiness and myotonia alone, without considerable cardiac conduction results, which can be critical for individuals with myotonic dystrophy who generally have fundamental cardiac issues.[270] However, modafinil is not really accredited by FDA for use in myotonic dystrophy, and the worth and position of modafinil in DM continue to be the subject of discussion.[270]
Belzutifan can be a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may well improve incidence or severity of adverse effects. Monitor for anemia and hypoxia and reduce belzutifan dose as proposed.
modafinil will enhance the degree or impact of diazepam buccal by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Sturdy or moderate CYP2C19 inhibitors could lower rate of diazepam elimination, thereby raising adverse reactions to diazepam.
Warfarin's considerably less strong R-enantiomer is metabolized partly by CYP3A4 (in addition to CYP1A2 and CYP2C19). Keep track of INR more often if coadministered with inhibitors of these isoenzymes and regulate warfarin dose if needed.
Although the evidence for these a variety of “improvement” effects is mostly rather weak, unlawful abuse of modafinil proceeds to generally be progressively prevalent between gurus and students.
stiripentol will boost the amount or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Carefully. Contemplate reducing the dose of CYP2C19 substrates, if adverse reactions are expert when administered concomitantly with stiripentol.